Produzione di emoglobina in cellule Eritroidi da pazienti con Beta Talassemia alterando processi biomolecolari in grado di regolare l’espressione dei geni per le globine
- 2 Anni 2010/2012
- 132.000€ Totale Fondi
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Pubblicazioni Scientifiche
- 2013 ARTIFICIAL DNA, PNA & XNA
Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation
- 2010 JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Effects of biomaterials for Lab-on-a-chip production on cell growth and expression of differentiated functions of leukemic cell lines
- 2015 PHARMACOLOGICAL RESEARCH
Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions
- 2011 CHEMMEDCHEM
Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)
- 2013 JOURNAL OF MEDICINAL CHEMISTRY
Psoralen Derivatives as Inhibitors of NF-kappa B/DNA Interaction: Synthesis, Molecular Modeling, 3D-QSAR, and Biological Evaluation
- 2011 BIOCHEMICAL PHARMACOLOGY
Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development
- 2012 PLOS ONE
Therapeutic Hemoglobin Levels after Gene Transfer in beta-Thalassemia Mice and in Hematopoietic Cells of beta-Thalassemia and Sickle Cells Disease Patients
- 2014 EXPERT OPINION ON THERAPEUTIC PATENTS
Peptide nucleic acids: a review on recent patents and technology transfer
- 2012 CURRENT TOPICS IN MEDICINAL CHEMISTRY
Dipeptide Inhibitors of Thermolysin and Angiotensin I-Converting Enzyme
- 2015 BIOMED RESEARCH INTERNATIONAL
Generation and Characterization of a Transgenic Mouse Carrying a Functional Human beta-Globin Gene with the IVSI-6 Thalassemia Mutation
- 2015 PLOS ONE
Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells
- 2011 EPIGENOMICS
miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs
- 2015 MOLECULAR DIVERSITY
Psoralen derivatives as inhibitors of NF- interaction: the critical role of the furan ring
- 2013 JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Induction of erythroid differentiation and increased globin mRNA production with furocoumarins and their photoproducts
- 2015 EXPERIMENTAL HEMATOLOGY
Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin
- 2012 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and beta-thalassemia patients
- 2012 ChemBioChem
Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells
- 2011 EXPERT OPINION ON THERAPEUTIC PATENTS
Recent patents on therapeutic applications of the transcription factor decoy approach
- 2011 EUROPEAN JOURNAL OF PHARMACOLOGY
C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells
- 2010 CHEMMEDCHEM
Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen
- 2012 ANNALS OF HEMATOLOGY
A combined approach for beta-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
- 2015 EUROPEAN JOURNAL OF PHARMACOLOGY
Erythroid differentiation ability of butyric acid analogues: Identification of basal chemical structures of new inducers of foetal haemoglobin
- 2012 MOLECULES
trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
- 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Peptide nucleic acids targeting beta-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells
- 2015 EXPERT OPINION ON THERAPEUTIC PATENTS
Recent patents and technology transfer for molecular diagnosis of beta-thalassemia and other hemoglobinopathies
- 2012 EPIGENOMICS
Involvement of miRNA in erythroid differentiation
- 2015 HUMAN BRAIN MAPPING
The Role of Iron in Gray Matter Degeneration in Huntingtons Disease: A Magnetic Resonance Imaging Study
- 2013 EXPERT REVIEW OF HEMATOLOGY
Combining gene therapy and fetal hemoglobin induction for treatment of ß-thalassemia
- 2011 ANALYTICAL CHEMISTRY
Direct Detection of Point Mutations in Nonamplified Human Genomic DNA
- 2012 EXPERT OPINION ON BIOLOGICAL THERAPY
Alternative options for DNA-based experimental therapy of beta-thalassemia
- 2014 EXPERT OPINION ON BIOLOGICAL THERAPY
Recent trends for novel options in experimental biological therapy of beta-thalassemia
- 2011 BMC BIOCHEMISTRY
Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines
- 2010 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
A preclinical approach for gene therapy of beta-thalassemia
