MITOCHONDRIAL FORMATION OF DNA-DAMAGING SPECIES AND MITOCHONDRIAL EVENTS LEADING TO CELL DEATH MEDIATED BY SHORT-CHAIN ORGANIC HYDROPEROXIDES IN MITOCHONDRIAL MYOPATHIES AND IN LATE-ONSET ALZHEIMER’S DISEASE

Pubblicazioni Scientifiche

• 2002 BIOCHEMICAL JOURNAL

  Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A(2)

• 1999 BIOCHEMICAL PHARMACOLOGY

  Apoptosis and necrosis following exposure of U937 cells to increasing concentrations of hydrogen peroxide: The effect of the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide

• 2001 EXPERIMENTAL CELL RESEARCH

  TNF alpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation

• 1999 JOURNAL OF NEUROCHEMISTRY

  Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells

• 2000 FREE RADICAL BIOLOGY AND MEDICINE

  Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA

• 2001 JOURNAL OF NEUROSCIENCE RESEARCH

  tert-butylhydroperoxide induces peroxynitrite-dependent mitochondrial permeability transition leading PC12 cells to necrosis

• 2000 FREE RADICAL BIOLOGY AND MEDICINE

  Products of the phospholipase A(2) pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells

• 2000 BRITISH JOURNAL OF PHARMACOLOGY

  Peroxynitrite-mediated release of arachidonic acid from PC12 cells

• 2001 FREE RADICAL RESEARCH

  Peroxynitrite promotes mitochondrial permeability transition-dependent rapid U937 cell necrosis: Survivors proliferate with kinetics superimposable on those of untreated cells

• 2001 BIOCHEMICAL JOURNAL

  Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells

• 2000 EUROPEAN JOURNAL OF NEUROSCIENCE

  Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively

• 1999 FEBS LETTERS

  Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate

• 2000 IUBMB LIFE

  Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA

• 2000 FREE RADICAL RESEARCH

  Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: The role of arachidonic acid