MECHANISM OF ACTION OF BOTULINUM NEUROTOXINS AND THEIR USE IN THE TREATMENT OF SPASTIC DISORDERS

Pubblicazioni Scientifiche

• 1996 JOURNAL OF CELL BIOLOGY

  VAMP synaptobrevin isoforms 1 and 2 are widely and differentially expressed in nonneuronal tissues

• 1995 JOURNAL OF PHYSIOLOGY-PARIS

  THE METALLOPROTEINASE ACTIVITY OF TETANUS AND BOTULISM NEUROTOXINS

• 1994 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  TETANUS AND BOTULINUM NEUROTOXINS ARE ZINC PROTEASES SPECIFIC FOR COMPONENTS OF THE NEUROEXOCYTOSIS APPARATUS

• 1995 METHODS IN ENZYMOLOGY

  TETANUS AND BOTULISM NEUROTOXINS - ISOLATION AND ASSAY

• 1994 JOURNAL OF BIOLOGICAL CHEMISTRY

  BOTULINUM-G NEUROTOXIN CLEAVES VAMP/SYNAPTOBREVIN AT A SINGLE ALA-ALA PEPTIDE-BOND

• 1995 EMBO JOURNAL

  VAMP-2 AND CELLUBREVIN ARE EXPRESSED IN PANCREATIC BETA-CELLS AND ARE ESSENTIAL FOR CA2+ - BUT NOT FOR GTP-GAMMA-S-INDUCED INSULIN-SECRETION

• 1994 MOLECULAR MICROBIOLOGY

  MECHANISM OF ACTION OF TETANUS AND BOTULINUM NEUROTOXINS

• 1995 BIOCHEMICAL JOURNAL

  VESICLE-ASSOCIATED MEMBRANE PROTEIN-2 (SYNAPTOBREVIN-2) FORMS A COMPLEX WITH SYNAPTOPHYSIN

• 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY

  X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin

• 1995 EUROPEAN JOURNAL OF BIOCHEMISTRY

  STRUCTURAL STUDIES ON THE ZINC-ENDOPEPTIDASE LIGHT-CHAIN OF TETANUS NEUROTOXIN

• 1994 NATURE

  SNARE MOTIF AND NEUROTOXINS

• 1996 JOURNAL OF BIOLOGICAL CHEMISTRY

  Clostridial neurotoxins and substrate proteolysis in intact neurons - Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa

• 1995 JOURNAL OF NEUROCHEMISTRY

  PHOSPHORYLATION OF VAMP SYNAPTOBREVIN IN SYNAPTIC VESICLES BY ENDOGENOUS PROTEIN-KINASES

• 1994 FEBS LETTERS

  BACTERIAL PROTEIN TOXINS PENETRATE CELLS VIA A 4-STEP MECHANISM

• 1995 JOURNAL OF BIOLOGICAL CHEMISTRY

  BOTULINUM NEUROTOXIN TYPE-C CLEAVES A SINGLE LYS-ALA BOND WITHIN THE CARBOXYL-TERMINAL REGION OF SYNTAXINS

• 1995 QUARTERLY REVIEWS OF BIOPHYSICS

  Structure and function of tetanus and botulinum neurotoxins