FUNCTIONAL CHARACTERIZATION OF LONG QT CAUSING MUTATIONS AND CHARACTERIZATION OF ACTIVATION AND INACTIVATION PROPERTIES OF THE KvLQT1/MINK POTASSIUM CHANNEL

Pubblicazioni Scientifiche

• 2003 BIOCHEMISTRY

  Molecular Modeling of p-chlorophenoxyacetic acid binding to the CLC-0 channels

• 2003 JOURNAL OF GENERAL PHYSIOLOGY

  Conformational changes in the pore of CLC-0

• 2003 NEURON

  Conservation of chloride channel structure revealed by an inhibitor binding site in CIC-1

• 2003 JOURNAL OF PHYSIOLOGY-LONDON

  Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels

• 2004 JOURNAL OF PHYSIOLOGY-LONDON

  Functional and structural conservation of CBS domains from CLC chloride channels

• 2000 BIOPHYSICAL JOURNAL

  Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels

• 2000 JOURNAL OF BIOLOGICAL CHEMISTRY

  Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy

• 2003 CIRCULATION RESEARCH

  Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels

• 1998 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

  Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK

• 2002 HUMAN MUTATION

  Myotonia caused by mutations in the muscle chloride channel gene CLCN1

• 2001 JOURNAL OF PHYSIOLOGY-LONDON

  Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels

• 2002 MOLECULAR PHARMACOLOGY

  Molecular requisites for drug binding to muscle CLC-1 and renal CLC- K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

• 2001 BRITISH JOURNAL OF PHARMACOLOGY

  A kinetic study on the stereospecific inhibition of KCNQ1 and I-Ks by the chromanol 293B

• 2002 MOLECULAR MEMBRANE BIOLOGY

  Mechanisms of block of muscle type CLC chloride channels (Review)

• 2000 JOURNAL OF GENERAL PHYSIOLOGY

  Fast and slow gating relaxations in the muscle chloride channel CLC-1

• 2001 JOURNAL OF PHYSIOLOGY-LONDON

  Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating

• 2001 JOURNAL OF GENERAL PHYSIOLOGY

  Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB)

• 2001 JOURNAL OF PHYSIOLOGY-LONDON

  Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S

• 1999 JOURNAL OF PHYSIOLOGY-LONDON

  Chloride dependence of hyperpolarization-activated chloride channel gates

• 1999 JOURNAL OF GENERAL PHYSIOLOGY

  The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia

• 2003 JOURNAL OF GENERAL PHYSIOLOGY

  Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic inhibitor