ANALYSIS OF TRANSMEMBRANE SIGNALING IN HUMAN IMMUNODEFICIENCY DISEASES: ROLE OF CD38 AND RELATED SURFACE RECEPTORS

Pubblicazioni Scientifiche

• 1997 JOURNAL OF IMMUNOLOGY

  Mapping of the catalytic and epitopic sites of human CD38/NAD(+) glycohydrolase to a functional domain in the carboxyl terminus

• 1996 CELLULAR IMMUNOLOGY

  Secretion of IFN-gamma, IL-6, granulocyte-macrophage colony-stimulating factor and IL-10 cytokines after activation of human purified T lymphocytes upon CD38 ligation

• 1996 FASEB JOURNAL

  Human CD38, a cell-surface protein with multiple functions

• 1997 JOURNAL OF IMMUNOLOGY

  Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide(+)-converting enzymes - Extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aply

• 1996 Blood

  Expression of cyclic ADP-ribose-synthetizing CD38 molecule on human platelet membrane

• 1997 TISSUE ANTIGENS

  Role of the human CD38 molecule in B cell activation and proliferation

• 1996 JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

  Monoclonal antibodies in clinical applications

• 1997 INTERNATIONAL IMMUNOLOGY

  gp120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules

• 1996 JOURNAL OF BIOLOGICAL CHEMISTRY

  Post-translational modification of CD38 protein into a high molecular weight form alters its catalytic properties

• 1996 JOURNAL OF IMMUNOLOGY

  Selective induction of CD73 expression in human lymphocytes by CD38 ligation - A novel pathway linking signal transducers with ecto-enzyme activities

• 1997 Blood

  Recombinant tumor necrosis factor enhances the locomotion of memory and naive B lymphocytes from human tonsils through the selective engagement of the type II receptor

• 1997 JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

  Functional associations of CD38 with CD3 on the T-cell membrane

• 1997 JOURNAL OF IMMUNOLOGY

  CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes

• 1997 JOURNAL OF BIOCHEMISTRY

  Potentiation of chemotactic peptide-induced superoxide generation by CD38 ligation in human myeloid cell lines