ANALYSIS OF APOPTOSIS IN NEURODEGENERATIVE DISEASES BY APAF1 CONDITIONAL MUTAGENESIS
- 5 Anni 2005/2010
- 880.000€ Totale Fondi
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Pubblicazioni Scientifiche
- 2007 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Autophagic and apoptotic response to stress signals in mammalian cells
- 2009 JOURNAL OF ALZHEIMERS DISEASE
Early Biochemical and Morphological Modifications in the Brain of a Transgenic Mouse Model of Alzheimer's Disease: A Role for Peroxisomes
- 2008 CELL DEATH AND DIFFERENTIATION
The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?
- 2008 AUTOPHAGY
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- 2007 CANCER BIOLOGY & THERAPY
Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance
- 2011 NATURE NEUROSCIENCE
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
- 2008 MOLECULAR BIOLOGY OF THE CELL
Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis
- 2010 CELL DEATH AND DIFFERENTIATION
Neuronal caspase-3 signaling: not only cell death
- 2007 MOLECULAR CELL
Nonapoptotic role for Apaf-1 in the DNA damage checkpoint
- 2007 AUTOPHAGY
A novel role for autophagy in neurodevelopment
- 2010 CELL DEATH AND DIFFERENTIATION
A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2
- 2007 NATURE
Ambra1 regulates autophagy and development of the nervous system
- 2009 CELL CYCLE
A novel player in the p53-mediated autophagy Sestrin2
- 2008 AUTOPHAGY
A dual role of p53 in the control of autophagy
- 2008 MICROBES AND INFECTION
Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells
- 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME
Apoptosis is not required for mammalian neural tube closure
- 2008 METHODS IN ENZYMOLOGY
Analysis of neuronal cell death in mammals
- 2008 PHARMACEUTICAL RESEARCH
The apoptosome: Emerging insights and new potential targets for drug design
- 2008 CELLULAR AND MOLECULAR LIFE SCIENCES
Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells
- 2011 JOURNAL OF CELL SCIENCE
Apaf1 plays a pro-survival role by regulating centrosome morphology and function
- 2006 APOPTOSIS
Apoptosome impairment during development results in activation of an autophagy program in cerebral cortex
- 2011 EMBO JOURNAL
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
- 2007 DEVELOPMENT
Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis
- 2008 DEVELOPMENTAL CELL
The role of autophagy in mammalian development: Cell makeover rather than cell death
- 2014 PLOS ONE
Altered Mitochondria Morphology and Cell Metabolism in Apaf1-Deficient Cells
- 2010 DEVELOPMENTAL BIOLOGY
Foregut separation and tracheo-oesophageal malformations: The role of tracheal outgrowth, dorso-ventral patterning and programmed cell death
